Not all payloads are carried to orbit in the Shuttle's cargo bay. In-cabin payloads are carried in the Shuttle's middeck. Cargo bay payloads are typically large payloads, such as satellites and Space Station modules, which do not require a pressurized environment. In contrast, in-cabin payloads are generally smaller, and are not usually designed for an unpressurized environment like the cargo bay.

Raffaello Multi-Purpose Logistics Module

The Raffaello Multi-Purpose Logistics Module will be making its second trip to the International Space Station during STS-108. The module will be filled with equipment and supplies to outfit the U.S. Destiny Laboratory, which was carried to the International Space Station on STS-98 in February 2001. Of the 16 racks the module can carry, this mission brings eight Resupply Stowage Racks and four Resupply Stowage Platforms.

• Avian Development Facility
• Commercial Biomedical Testing Module Experiment
• Starshine 2